Coffee Polyphenols Mitigate Cognitive Deficits Caused by Stress

Coffee
Spread the love

New Study Shows That Coffee Compounds Can Protect the Brain

According to a recent study published in Neurobiology of Stress the chronic early-life stress induced cognitive impairments can be mitigated by coffee’s polyphenols. Mice were found to benefit from dietary supplementation with 0.02% chlorogenic acid and 0.02% caffeic acid which are two crucial constituents of coffee polyphenols.

Understanding Coffee Polyphenols

These are phytochemicals that function as antioxidants like chlorogenic acids, flavonoids, and lignans. Such molecules shield cells from oxidative stress and alleviate inflammation that could result in chronic diseases such as diabetes and cardiovascular disease. Additionally, they aid cognition while possibly staving off age-related neurodegenerative disorders such as Alzheimer’s.

Chlorogenic acid is abundant in coffee and has been associated with better glucose metabolism and reduced risks of several chronic diseases. Coffee has another phenol called caffiec acid which is less common but also enjoys similar benefits because it guards against oxidation damage.

The Aim & Methodology Of The Research

Geertsema Jorine among other researchers sought to determine if addition of growing mice’s diet with chlorogenic and caffeic acid would protect them from cognitive impairment brought about by early-life stress. Early-life stress is known to decrease hippocampal neurogenesis or the production of new neurons by the brain; this leads to increased inflammation resulting into cognitive decline later in life.

In total, there were 47 male mice split into four groups whereby two received standard grain-based meal while other two consumed the same food containing an addition of 0.02% chlorogenic acid and 0.02% caffeic acid since day second till forty-two after birth. They were weaned at day twenty one while all groups continued on their respective diets up to day forty two when they were put on normal diet.

In each pair of dietary groups, one group was exposed to prenatal stress. Early-life stress was induced through restriction of bedding material and a 1 cm above-bedding sheet made from steel mesh.

Behavioural and Biological Assessment

Three behavioral tests including the Morris water maze (MWM), object recognition task (ORT) and the object location task (OLT) were conducted on the mice at four months of age in order to evaluate their cognitive function. Furthermore, researchers evaluated microglia quantity (which are immune cells for brain) and how well hippocampal neurogenesis is occurring within mouse’s brain tissues.

Key Results

Initially, mice undergoing early-life stress gained less weight while those on polyphenol supplement had more weight compared to their counterparts on standard diet during this period. The difference in weights between these groups had vanished by day 42.

Behavioral experiments demonstrated that early life stresses resulted into cognitive deficits as well as reduced numbers of microglia in the hippocampus among mice that were kept on a basal diet medication. Nevertheless, there was no such decline regarding mental functioning or reduction in microglia for mice receiving supplemented diets with polyphenols.

The study authors propose that coffee polyphenols protected the mice against cognitive impairments by sustaining microglia survival in the brain which can be due to other pathways linked with chlorogenic acid’s antioxidant and anti-inflammatory properties.

Implications and Future Research

“The supplementation of polyphenols in a diet emerges as a promising avenue for nutritional intervention in the context of mitigating the detrimental cognitive effects of ES [early stress] in males which are associated with microglial changes,” the study authors concluded.

Even though mice have many physiological similarities with humans, they are different species, thus what happens on mice might not play out the same way on humans. However, this study was conducted on mice, not humans.

Additionally, studying the potential benefits of these compounds in females and their effects when administered at different life stages would be valuable. Future research should investigate whether these findings can be replicated in humans and explore the precise mechanisms through which coffee polyphenols exert their protective effects.

J. Geertsema, M. Kratochvil, R. González-Domínguez, S. Lefèvre-Arbogast, D.Y. Low, A. Du Preez, H. Lee, M. Urpi-Sarda, A. Sánchez-Pla, L. Aigner, C. Samieri, C. Andres-Lacueva, C. Manach, S. Thuret et al., “Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice.”



Spread the love

Leave a Reply

  • Academic Streaming Leads To Poor Mental Health In Children: Study Finds

    Academic Streaming Leads To Poor Mental Health In Children: Study Finds

    Research delves into the ill impact of academic streaming.

  • Early Retirement Accelerates Cognitive Decline: Research Claims

    Early Retirement Accelerates Cognitive Decline: Research Claims

    Research delves into the negative mental health benefits of early…

  • Relationships With Narcissists Can Trigger PTSD: Study Finds

    Relationships With Narcissists Can Trigger PTSD: Study Finds

    Research delves into the link betwen narcissism and PTSD in…

  • How Do TikTok and Other Social Media Sites Promote Depression As A Marketing Tool?

    How Do TikTok and Other Social Media Sites Promote Depression As A Marketing Tool?

    Experts delve into how social media sites use mental illness…

  • Females Have Greater Cognitive Empathy Than Males: Study Finds

    Females Have Greater Cognitive Empathy Than Males: Study Finds

    Research delved into the gendered nature of cognitive empathy.

  • Science Answers The Age-old Question: “Why Do People Like Villains?”

    Science Answers The Age-old Question: “Why Do People Like Villains?”

    Researchers explored the psychology behind approaching villains in pop-culture.

  • Celebrations Can Benefit Your Mental Health: Study Finds

    Celebrations Can Benefit Your Mental Health: Study Finds

    Research delves into the mental health benefits of celebrations.

  • Why Women Still Do More Household Chores Than Men: Study Reveals

    Why Women Still Do More Household Chores Than Men: Study Reveals

    Researchers apply the “affordance theory” to explain the inequality in…

  • Does Smoking Increase Memory Loss? Surprising Study Results

    Does Smoking Increase Memory Loss? Surprising Study Results

    Research delves into the link between smoking and midlife cognitive…

  • Science Reveals What Comprises “Teacher Expertise”

    Science Reveals What Comprises “Teacher Expertise”

    Research delves into the qualities of exceptional teachers.

  • Should We Fear The Return Of The “Heroin Chic” In Wellness And Fashion?

    Should We Fear The Return Of The “Heroin Chic” In Wellness And Fashion?

    Experts highlight the downsides of the “heroin chic” body and…

  • Study Finds Why People Sleep Least From The Early 30s To 50s

    Study Finds Why People Sleep Least From The Early 30s To 50s

    Research delves into how sleep patterns fluctuate with age.

  • Spare: Surprising Revelations About Prince Harry And Agoraphobia

    Spare: Surprising Revelations About Prince Harry And Agoraphobia

    How the royal tell-all “Spare” sheds light on Britain’s Prince…

  • Music Supports Stroke Rehabilitation: Study Finds

    Music Supports Stroke Rehabilitation: Study Finds

    Research delves into the benefits of singing-based stroke rehabilitation.

  • Adverse Childhood Experiences Lead To Poor Midlife Mental Health: Study

    Adverse Childhood Experiences Lead To Poor Midlife Mental Health: Study

    Research delves into the link between negative childhood experiences and…

  • Buddhism Reduces Risks Of Depression, Surprising Study Finds

    Buddhism Reduces Risks Of Depression, Surprising Study Finds

    Research delves into the mental health benefits of Buddhism.

  • What Is The Role Of Artificial Intelligence In Mental Health?

    What Is The Role Of Artificial Intelligence In Mental Health?

    Experts delve into the power of artificial intelligence (AI) in…

  • Aging And Stress: Does Daily Stress Decreases As People Age?

    Aging And Stress: Does Daily Stress Decreases As People Age?

    Research delves into the relationship between aging and stress.

  • Are Prenatal Wellness Classes Beneficial For Moms? Research Reveals

    Are Prenatal Wellness Classes Beneficial For Moms? Research Reveals

    Experts highlight the benefits of prenatal wellness classes.

  • Hearing Is Believing: Can Sounds Alter Our Visual Perceptions?

    Hearing Is Believing: Can Sounds Alter Our Visual Perceptions?

    Research delves into how sounds influence our visual perceptions.

  • The Sandwich Generation Stress: Caring For Kids and Aging Parents

    The Sandwich Generation Stress: Caring For Kids and Aging Parents

    Researchers delve into the intricacies of the “sandwich generation” stress.

  • Introverts And Depression: Are Introverts Prone To Mental Health Issues?

    Introverts And Depression: Are Introverts Prone To Mental Health Issues?

    Research delves into the link between introverts and depression.

  • Pregnant Moms’ Stress Negatively Affects Their Children: Study Finds

    Pregnant Moms’ Stress Negatively Affects Their Children: Study Finds

    Research explored the link between pregnant moms’ stress and their…

  • Did You Know e-Tattoo Can Detect When You’re Stressed Out?

    Did You Know e-Tattoo Can Detect When You’re Stressed Out?

    Research devised a palm e-tattoo that can detect mental distress.

  • Playing The Piano Boosts Brain Health: Study Says

    Playing The Piano Boosts Brain Health: Study Says

    Research explores the mental health benefits of playing the piano.

  • Netflix’s “The Midnight Club” Highlights Teen Mental Health And Terminal Illness

    Netflix’s “The Midnight Club” Highlights Teen Mental Health And Terminal Illness

    How Netflix’s “The Midnight Club” explores teen mental health against…

  • Can Fearlessness Be Taught?

    Can Fearlessness Be Taught?

    Research explores the neural mechanisms behind learning fearlessness.